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The mechanism likely involves anti-inflammatory effects, improved endothelial function, and direct vascular benefits beyond what weight loss alone would provide
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However, the drink plenty of water caveat is crucial, as dehydration can exacerbate constipation from GLP-1 drugs, especially with the appetite-suppressing effects potentially leading to reduced fluid intake for those taking GLP-1 for weight management
NICE guidance emphasises that weight management interventions should be multicomponent, addressing dietary intake, physical activity levels, and behaviour change strategies
