Impaired system Xc activity has been linked to xCT subunit inactivation (148), which sustains glutamate excitotoxicity in rat models of cerebral ischemia (149)
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264,265,266 Keap1 is an adaptor of cullin-based E3 ubiquitin ligase that suppresses the transcriptional activity of Nrf2 via inducing its ubiquitination and proteasomal degradation
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