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Mechanisms That May Explain Enhanced Weight Loss Reduced energy intake GLP-1 receptor activation reduces appetite and food intake through hypothalamic, hindbrain, vagal, and gastrointestinal mechanisms
GLP-1 receptor agonists are typically added when metformin alone is insufficient
Gaq/11 activation and IP3-mediated calcium mobilization Systemic (Preclinical) Longitudinal bone growth in rodent studies
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