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Instead, GLP-1 promotes the polarization of Th2 and regulatory T (Treg) cells, increasing anti-inflammatory cytokines such as IL-10 and IL-5 (55, 56)

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The biological evidence is robust at the cellular level, and clinical results are promising but limited by small study sizes, industry sponsorship, and absence of independent replication

Supporting this hypothesis, a chronic unpredictable mild stress mouse model demonstrated that melatonin effectively restored aquaporin-4 polarization and rectified the compromised glymphatic system observed in this model [215]