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It was discovered in 2012,[3] by a team of researchers at Novo Nordisk as a longer-acting alternative to liraglutide.[4] Clinical trials were started in 2015, and phase 3 was completed in 2016.[5] Researchers at the University of Leeds and Novo Nordisk reported in 2017 that it can also be used for the treatment of obesity.[6] It reduces hunger, food craving and body fat.[7] FDA approval was applied in December 2016, and in October 2017 FDA Advisory Committee voted 16-0 in favour.[8] On December 5, 2017, semaglutide was approved by the US FDA

Semaglutide belongs to a class of medications called GLP-1 receptor agonists, and when it is taken, it can activate certain receptors in the brain

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Patients should contact their healthcare provider if they experience severe or persistent vomiting that prevents adequate fluid or medication intake, as this can lead to dehydration and electrolyte imbalances

10.1016/J.TIV.2017.10.020 41 CrookeS

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