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Although considerable scientific advances have enhanced our understanding of EED reproductive toxicity, significant knowledge gaps remain that require continued mechanistic research, improved biomonitoring approaches, and evidence-based intervention strategies

This means two women with identical total testosterone levels can have very different symptoms depending on their SHBG levels

By age 60, levels drop to around 80 ng/mL, a 60% reduction

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Smooth muscle-selective inhibition of nuclear factor-B attenuates smooth muscle phenotypic switching and neointima formation following vascular injury

But that improvement stopped after they stopped taking it (25)