[3] Initial treatment of pernicious anemia typically consists of 1,000 mcg intramuscularly daily for one week, then weekly for four weeks, transitioning to 1,000 mcg monthly for life
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vant Hoff WG, Gretz N (1995) The treatment of cystinosis with cysteamine and phosphocysteamine in the United Kingdom and Eire
However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig
& Selph, S
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