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J Neurochem 1994, 62: 1137-1143

The medication's effects are generally dose-dependent, though the optimal dose should be determined based on both efficacy and tolerability

The specific mechanisms by which these plants may protect tissues from drug toxicity, exert antioxidant effects, regulate immune function, and control thyroxine levels remain largely unexplored

Of interest, an enlarged dorsal muscle area was noted in gilthead seabream fed diets supplemented with 2%, 5%, or 8% creatine [42]

Despite the limitations, these data suggest that long term therapy is not associated with durable weight loss with withdrawal of the medication and supports guidelines for extended therapy

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