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It consists of the tripeptide GHK complexed with a divalent copper ion (Cu 2+ )

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The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme

Jackman TM, Hussein AI, Curtiss C, et al

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doi: 10.1038/sj.bjp.0707462 51 JenhCHCoxMACuiLReichEPSullivanLChenSCet al