These small differences in efficacy of BLX2477 may be explained by the 3-log higher IC 50 of BLX2477 for free versus PE-esterified eicosatetraenoic acid (ETE) (Supplemental Figure 3)
Impact of high-fat diet on cognitive behavior and central and systemic inflammation with aging and sex differences in mice
Serious side effects include Severe Allergic Reactions: Difficulty breathing, severe itching, hives, and swelling of the face or throat are signs of anaphylaxis, a severe allergic reaction
Local anesthesia: Patients are awake during the procedure, which is done under local anesthesia, similar to a thyroid biopsy or a dental cavity filling
Finding the right medication combination and dosages often takes time and patience
We may not yet know exactly why, and hopefully one day we will, but that seems to be a much more sure path to the desired outcome