The ones who try to silence dissent are the ones with something to hide
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Loading Dose When the time to reach steady state is appreciable, as it is for drugs with long half-lives, it may be desirable to administer a loading dose that promptly raises the concentration of drug in plasma to the target concentration
Bhupathiraju SN, Tobias DK, Malik VS, Pan A, Hruby A, Manson JE,
Cancer risk among people with type 1 and type 2 diabetes: disentangling true associations, detection bias, and reverse causation
Once the lyophilized cake is partially dissolved, there is no way to accurately divide the remaining powder