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High levels of IGF-1 can trigger the bodys negative feedback loop, potentially suppressing natural GH release over time

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Waist circumference decreased by a mean of 23.4 cm in the 12 mg arm

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However, this attempt failed and this approach did not prove successful until the introduction of the incretin hormone glucagon-like peptide-1 (GLP-1) as the basis for glucose-lowering therapeutics in type 2 diabetes

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