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Mitochondrial -oxidation of VPA involves its transport within 2 the mitochondrial matrix, using the same pathway as do long-chain fatty acids

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The risk-benefit profile of triple agonists remains under investigation

Together, these three mechanisms, coordinated neuronal energy support, reduced neuroinflammation, and complementary synaptic maintenance, make the combination of HRT and GLP-1 receptor agonists particularly relevant for the preservation of cognitive resilience during the menopausal transition and beyond