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In laboratory studies, inhibiting NNMT has been investigated for effects on cellular NAD+ levels and adipocyte (fat-cell) metabolism

It does this by activating a protein called the vascular endothelial growth factor which initiates the formation of new blood vessels

However, more extensive clinical trials are necessary to establish long-term effects on glycemic control and complications

10.1016/j.ebiom.2019.11.026 32 BirsaN.BenthamM

You can keep your vitamin B12 levels where they should be, even with many medicines

"Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation?"