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Sekiguchi N, Kameda H, Amano K, Takeuchi T: Efficacy and safety of bucillamine, a D-penicillamine analogue, in patients with active rheumatoid arthritis

10.1016/j.intimp.2023.110436 Summary Keywords inflammation, lung injury, carnosine, immune homeostasis, metabolomic profiling Citation Ruan L, Lin D, Lin B, Zhan Q, Zheng L, Lin D, Zhuang Y and Zeng Y (2025) Carnosine as a protective metabolic mediator in inflammatory lung injury by inhibiting macrophage infiltration and M1-like polarization

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

For example, selective serotonin reuptake inhibitors (SSRIs) increase serotonin in patients with low levels

Repeated freeze-thaw cycles can damage the delicate peptide structure