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Kirkman HN et al

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The ER membranes must be fluid and compliant to accommodate nascent membrane proteins with diverse physical properties (Sharpe et al., 2010) but may require local regions to facilitate protein sorting or export (Halbleib et al., 2017

Methods In this phase 3a, double-blind, randomized, placebo-controlled trial conducted in 12 countries, we assigned adults with a body-mass index of 27 or more, a glycated hemoglobin level of 7 to 10%, and type 2 diabetes in a 3:1 ratio to receive once-weekly cagrilintide-semaglutide (2.4 mg each) or placebo, along with lifestyle intervention, for 68 weeks