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Galantamine, which was approved in 2001 by the FDA, is an allosteric modulator of nicotinic and acetylcholine receptors and a competitive inhibitor of acetylcholinesterase
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It requires clinical trials, in-depth review of both the safety and efficacy of each drug, and continuous monitoring afterward
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It is a GRAS-certified substance, meaning it has been determined by the FDA to be Generally Recognized as Safe
In the coming decades, the challenges in the field of T21 will involve not only identifying effective therapies to mitigate cognitive defects but also understanding the molecular and cellular mechanisms underlying the characteristic phenotype resulting from genetic triplication
