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The difficulty of manufacturing increases exponentially with larger and more complex pneunets

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For short-term use (typically up to seven days), prednisolone is considered safe for most adults and does not usually require dose tapering

Mori MP, Penjweini R, Knutson JR, Wang P, Hwang PM

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The theoretical benefit compared to the peptides is reduced receptor desensitisation and a different tolerability profile, though whether that translates to clinically meaningful differences in nausea, vomiting and discontinuation rates is still under investigation