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Furthermore, gradual sequencinginitiating metformin or myoinositol in treatment-nave patients, followed by glucagon-like peptide-1 receptor agonist (GLP-1 RA) introduction if weight loss or metabolic targets remain unmetcould personalize therapy while maintaining tolerability and cost-effectiveness

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In addition, labile iron pools can catalyze lipid radical propagation through Fenton-type reactions, further amplifying membrane lipid peroxidation [71, 72]