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Since obesity is a chronic condition, long-term treatment is typical and appropriate

Data availability The source data supporting the findings of this article are included in this article and its supplementary information files

Each of these classes has distinct structures and biological activities

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T/T individuals supplementing with 5-methylfolate (active folate), methylcobalamin, and pyridoxal-5'-phosphate normalize homocysteine, restore BH4 recycling, and reduce functional methylation insufficiency across most downstream longevity mechanisms