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Proc Natl Acad Sci U S A 99:1190813 Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S (2009) Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
& Yu, S
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After the trial period, 36% of participants on semaglutide met a composite goal of 70% timeinrange, minimal hypoglycemia and 5% weight loss, versus 0% on placebo
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Why the dual mechanism matters The GIP receptor does something interesting: it appears to affect how fat tissue responds to insulin and may reduce the inflammatory signals that make weight loss harder
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