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The goal of titration is finding your minimum effective dose, not reaching the maximum

The use of methotrexate may additionally invalidate diagnostic assays for folic acid and vitamin B12

Campagna, R., et al

4.7 Negative aspects of treatment as perceived by pet owners Negative perceptions of treatment included frustration with the unpredictability and inconsistency of pet treatments where veterinarians try multiple medications or methods without reliable results. (Ineffectiveness and trial-and-error of treatments theme, Section 3.5.5)

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