Food and Drug Administration (FDA) recently announced the end of shortages that have plagued popular weight-loss drugs, like Zepbound and Novo Nordisks (NVO) Wegovy
Its primary mechanism is cellular and chronobiological
It was a complementary fat-burning lever that added efficacy without the tolerability cost
Overwashing, especially with harsh soaps, can strip the skin of its natural oils and lead to dryness
This makes it particularly interesting for researchers focused on the neurological underpinnings of obesity and eating disorders
There are also some very exciting recent data showing how these medications may work not just on GABA or just on dopamine, which is the canonical way we conceive of reward processing, but by working on both by modulating GABA transmission for example, at the ventral tegmental area and dopamine transmission at the nucleus accumbens