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TLR signaling molecules, like mitogen-activated protein kinases (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), play fundamental roles in TLR-mediated cell proliferation and survival via reducing apoptosis and increasing time for viral replication (Li et al., 2010

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In addition, the treatment with the Chinese herbal monomer Rubus chingii Hu can inhibit the activation of the TXNIP/NLRP3 inflammasome in the ovarian tissue of PCOS rats and improve the polycystic development of the ovaries (85)

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