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Metabolism slows, muscle mass declines, hormonal shifts alter how the body stores fat, and the caloric deficit required to produce meaningful weight loss becomes more difficult to sustain through diet and exercise alone

Mol Metab 2018;11:33-46.ArticlePubMedPMC 69

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2 Materials and methods 2.1 Study design This systematic review and NMA was conducted according to the methodological standards outlined in the Cochrane Handbook for Systematic Reviews of Interventions (55)

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