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Oxidative stress is a recognized contributor to heart failure progression [29], [30], and previous studies have pointed out changes in the redox status of glutathione in the failing heart

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In particular, reduced glutathione , often referred to in its fully active form, is the one doing all the heavy lifting

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In addition to Nrf2, activation of PPAR- and the AMPK pathway can also facilitate the GSH system

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Moreover, comparative investigations often help laboratories establish consistent evaluation standards across multiple projects

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