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We observed that many signature genes completely lack, or have very little, NRF2 ChIP-seq signal within 1 kb of their promoter (Fig

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This trend was also observed at different dose levels and regimens within a week with platinum concentration in the lung tumour 2fold (with 0.5 mg/kg/day x 3 days), 4fold (with 0.5 mg/kg/day x 5 days) and up to 6 fold higher (with 1 mg/kg/day x 5 days) than in tumourfree lungs

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