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Insufficient protein accelerates muscle breakdown, and since muscle tissue drives metabolic rate, losing muscle makes fatigue worse
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The pivotal obesity trials Lilly needs for a commercial label, TRIUMPH-1 and TRIUMPH-3, are still running and read out across 2026
Additionally, the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and fibroblast growth factor 21 receptor (FG21R) also significantly influence these metabolic processes