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To investigate the effect of hypocarnitinemia on MAD efficacy, we assessed the percentage change in the number of seizures between patients with low free carnitine and normal free carnitine for each follow up timepoint
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To our knowledge, the most studied and understood mitophagy pathway is mediated by PTEN-induced kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin (Narendra et al., 2008