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PET tracer studies (e.g., [^11 C]-PK11195, [^18F]-DPA-714) have revealed chronic microglial activation in vivo, which correlates with motor symptom severity and nigrostriatal dopamine depletion

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Vit-D could also inhibit NF-B activation to down-regulate proinflammatory cytokine synthesis and other key activators of cell-mediated immunity 692

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