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The detoxification reactions comprise the first four steps of mercapturic acid synthesis, [19] with the conjugation to GSH serving to make the substrates more soluble and allowing them to be removed from the cell by transporters such as multidrug resistance-associated protein 1 (MRP1)
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One key player in this narrative is glutathione, a potent antioxidant that plays a vital role in detoxification, immune function, and cellular health
In in vitro granuloma models, everolimus not only controlled M.tb growth but also demonstrated an additive effect when combined with front-line anti-TB drugs like isoniazid and pyrazinamide
34 Such chemistry is likely to be relevant in dense epithelial sheets, aligned muscle fibers, and compact tumor nests, where adjacent plasma membranes lie in close proximity and often share similar lipid composition, iron availability, and redox conditions
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