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A meta-analysis of 113 RCTs comprising 33,167 patients in the GLP-1 RA cohort and 26,683 in the comparator cohort revealed no significant elevation in pancreatitis or pancreatic cancer risk relative to control groups (Mantel-Haenszel odds ratio [MH-OR] of 0.93 and 0.94, respectively), but identified a notable increase in cholelithiasis risk (MH-OR, 1.30) [58]
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Front Endocrinol (Lausanne) 12 , Liu, X., Patel, K
In fact, rodent studies have shown that GLP-1 might downregulate dopamine transmission and potentially blunt reward-seeking behavior
Processing of preproglucagon in enteroendocrine L-cells results in the production of four forms of GLP-1 [GLP-1(1-36)NH 2 , GLP-1(7-36)NH 2 , GLP-1(1-37), and GLP-1(7-37)], GLP-2, glicentin, and oxyntomodulin
Both animal and human studies demonstrate that LPS stimulate GLP-1 release via Toll-like receptors (TLRs)
