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In db/db mice and HG-exposed HK-2 cells, overexpression of mitofusin 2 restores mitochondrial function, suppresses mitochondrial oxidative phosphorylation, reduces tubular apoptosis and eventually alleviates diabetic kidney injury, and the reverse tendency is observed in mitofusin 2 short hairpin RNA treated db/db mice (82)
De Angelis F, Connick P, Parker RA, Plantone D, Doshi A, John N, et al
Experientia Supplementum
The relevance of physical and psychosocial factors for the quality of life in patients with thyroid-associated orbitopathy (TAO)
The argument is that this will deliver higher levels directly into muscles or bloodstream and makes the treatment more efficient than oral supplements