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In clinical trials, people taking tirzepatide for weight loss lost an average of about 21% of their starting body weight
Most side effects are manageable and do not require discontinuation of the medication
By contrast, many patch products are marketed as wellness or supplement items and may not contain an approved GLP-1 medicine at all
The search for safe and effective pharmacologic weight-loss agents began in the late 19th century with the discovery that sheep thyroid extract increased metabolic rate and induced significant weight loss
Statistical significance was estimated using Students t -test or the analysis of variance followed by Bonferronis t -test as described in the legends
The MHRA approval confirms the medicines authorisation, not a universal retail price
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