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IPA accumulation demonstrates biphasic mitochondrial regulation: acute exposure (30 min) enhances maximal mitochondrial respiratory capacity, while chronic exposure (24 h) significantly inhibits complexes I/II/IV activity and fatty acid oxidation, reducing oxygen consumption rates (Gesper et al., 2021)
Wright JM, Binnie WH, Byrd DL, Dunsworth AR
Disadvantage: risk of degradation if exposed to moisture or heat 6
Pennsylvania is planning to limit Medicaid coverage to beneficiaries at the highest risk of complications from obesity
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