doi: 10.1038/s41591-024-03038-y 215 WangL.WangY.XuH.LiW
Semaglutide mimics the effects of GLP-1
Genetic variations in the expression of drug transporters in the gut wall (e.g., P-glycoprotein) can cause significant inter-individual differences in drug absorption
It plays a crucial role in regulating various cellular processes, including metabolism, cell cycle progression, apoptosis, and oxidative stress response
We need to prove that there is a long term health benefit for patients and the healthcare system
They were sued in August 2023 by a Louisiana woman Jaclyn Bjorklund, who alleged the companies downplayed the severity of the gastrointestinal events caused by Ozempic and Mounjaro, and in particular played down the risk of gastroparesis, which is the slowing or stopping of the digestive system