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In cohort studies, combination therapy was associated with a lower risk of MACE (RR 0.56 [95% CI 0.43, 0.71]

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doi:10.1042/bse0340139

Dysbiosis-driven aberrations in microbial composition and activity disrupt the production of these metabolites, compromising intestinal barrier integrity, fueling chronic low-grade inflammation, and exacerbating insulin resistance

All use must follow institutional and regulatory guidelines