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Without adequate B12, these processes cannot proceed efficiently, potentially leading to significant health consequences

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However, about 10-15% of acetaminophen is metabolized by CYP2E1 into a toxic metabolite known as NAPQI (N-acetyl-p-benzoquinone imine).[ref] Detoxification with glutathione: NAPQI then needs to be neutralized with glutathione, which is catalyzed using the GST genes

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As these mechanisms are well established, readers are referred to comprehensive reviews for detailed molecular descriptions of autophagy pathways