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Diagnostic evaluation may include: Detailed neurological examination assessing sensation, reflexes, and motor function Hemoglobin A1c measurement to evaluate recent glycemic control Vitamin B12 levels and methylmalonic acid (if B12 is borderline) Serum protein electrophoresis (SPEP) and immunofixation to screen for paraproteinemia Thyroid function tests, as hypothyroidism can contribute to neuropathic symptoms Comprehensive metabolic panel to assess renal and hepatic function Nerve conduction studies in selected cases with atypical features Management strategies focus on optimizing glycemic control, which remains the most evidence-based intervention for preventing and potentially improving diabetic neuropathy

1989 Oct;38(10):957-61

10.3389/fnbeh.2014.00326 Front

Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: results from a randomized controlled trial in patients with type 2 diabetes

Mild warmth, swelling, or bruising that takes a few days to resolve

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