Biomedicine & Pharmacotherapy, 57 (34), 145155
As such, reducing insulin resistance and supporting healthy weight are important goals in the overall treatment and management of PCOS ( 1 , 3 )
Overall, although the overall absolute risk increase is small (27 cases per 10,000 persons treated per year), clinical practitioners should nevertheless take into account the potential risk of gallbladder or biliary diseases associated with GLP-1RAs, especially when used at higher doses, for longer durations, and for weight loss, and in case the patient has a history of lithiasis [64]
As a result, MTX was synthesised as a folic acid antagonist to treat childhood leukaemia with great success, as was proved in the landmark trial reported in 1948 [14]
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