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doi: 10.3389/fendo.2019.00777 Received 01 July 2019 Accepted 24 October 2019 Published 12 November 2019 Volume 10 - 2019 Edited by David Gregory Mottershead, Keele University, United Kingdom Reviewed by Briony Forbes, Flinders University, Australia

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The physicochemical stability of BPC-157 across various biological environments may contribute to its apparent safety profile, as the peptide appears to be well-tolerated when administered via different routes including oral, subcutaneous, and intramuscular administration

When 5 mg/day MK-4 was used there was a significant improvement in carboxylation of VKDPs, with no additional benefit compared to 45 mg/day MK-4.56 In addition, there is a synergistic relationship between vitamin K and vitamin D