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Some studies suggest the quinolinium structure is sufficiently NNMT-selective that it should not broadly deplete SAM, but the wider metabolic picture remains an active research consideration

Injectable effects Reported injectable effects are mostly local: redness, mild swelling, transient warmth, or a slight blue-tinted bruise from the copper complex

For instance, a study by Grace et al., on lambs receiving a single 2 mg subcutaneous B12 injection demonstrated significant increases in serum and liver B12 concentrations for up to 24 days compared to untreated animals (2)

GHK-Cu demonstrated anti-anxiety effects in rats at an extremely low dose of just 0.0005 mg per kilogram of body weight, producing measurable behavioral changes within 12 minutes of injection

This ensures faster absorption, especially in people with vitamin B12 deficiency