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Atorvastatin also improved microvascular reactivity and reduced the oxidative stress marker malondialdehyde in patients with HFpEF (Iacovelli et al., 2024), and Simvastatin significantly decreased protein carbonylation (an oxidative stress marker) in COPD patients

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Potential concerns include unknown long-term safety, product quality variability, and theoretical risks related to angiogenesis and tumor growth

Patients should use a validated sedation scale (such as the Ramsay Sedation Scale or a simple self-reported drowsiness log) during the first 4 weeks of combination therapy