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Escalation beyond 2mL weekly is uncommon and increases cardiovascular risk through elevated homocysteine without proportional metabolic benefit
On GLP-1 therapy like semaglutide, plateaus are completely normaltypically occurring after substantial early results
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It may also boost gut health, increase blood flow, and reduce pain
Some of the biggest causes of concern are if these symptoms become severe, patients experience abdominal pain, dietary and lifestyle changes offer no relief, or there are symptoms of pancreatitis
doi: 10.1038/d41586-022-00382-2 102 MontoyaJGKogelnikAMBhangooMLunnMRFlamandLMerrihewLEet al
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