Semaglutide, a GLP-1RA, mitigates seizure severity and cognitive impairment through the inhibition of the lipopolysaccharide (LPS)- and nigericin-induced NLRP3 inflammasome pathway, reducing lactate dehydrogenase (LDH) release by microglial cells [53]
Last updated on July 2, 2026 GLP-1 medications like Ozempic and Wegovy are everywhere right now from social media to billboards
Exendin-4 treatment improves LPS induced depressive-like behavior without affecting pro-inflammatory cytokines
GLP-1RAs promote glucose uptake in the skeletal muscle by increasing microvascular blood flow and tissue perfusion and inhibit muscle catabolism via the AMP-activated protein kinase pathway [39, 77, 83]
A Review on the Efficacy and Safety of Oral Semaglutide
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