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Additionally, a 1-year randomized Phase II clinical trial in patients with atrophic macular degeneration showed a favorable safety profile and benefits for vision maintenance (184)
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While typically synthesized endogenously, Gln becomes conditionally essential during physiological stress, requiring dietary intake to meet increased demands (Brosnan 2003
Due to the unclear and complicated pathobiology of MS-related depression (3, 10), further clinical and experimental investigations are needed to clarify and understand the molecular mechanisms of depression origin in MS patients and provide effective and practical therapeutic approaches
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