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In brief, we established consensus that: GLP-1RAs benefits outweigh potential ocular risks Current evidence points to early diabetic retinopathy worsening being mainly linked to rapid glucose reduction We explore the pathomechanistic reasons for the association with NAION Cross-disciplinary collaboration and screening are vital Enjoy reading and let me know what you think

Each escalation produces another shorter, milder wave of nausea and reflux that typically resolves in under a week

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Same molecule = same mechanism

Phase 3 TRIUMPH-4 results (December 2025): The 12mg once-weekly dose achieved 28.7% mean body weight loss over 68 weeks