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Safety and side effects: A meta-analysis of multiple studies in COPD patients showed no significant adverse effects at doses ranging from 600 mg to 3g/day.[ref] Studies in healthy adult athletes go up to 20g/day (not recommending this, just including it for safety).[ref] Conversely, in Parkinsons patients, there was a high number of adverse events at 6g/day of NAC

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Starting with lower doses (100-200mg) and increasing gradually helps minimize digestive effects and allows assessment of individual tolerance