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Participants maintaining the highest 12 mg dose of retatrutide lost an average of 30.3% of their body weight (38.5 kg) at 104 weeks, while those moving from the lowest 4 mg dose to the maximum tolerated dose lost an average of 27.9% of their body weight (33.2 kg)

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The post names severe gastroparesis, pending abdominal surgery, and a history of chronic pancreatitis as reasons an injectable alternative may be more appropriate than an oral formulation

Virologic outcomes during DOR use were not assessed for this study