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These may include headache, fatigue, body aches, or a general feeling of malaise
therapy requires trained medical personnel for administration, thus raising costs, patient burden for clinic visits, and risk of discomfort and phlebitis
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CRF and the urocortins function through two G protein-coupled receptors, CRF1 and CRF2
This made it possible to discover peptides in low abundance, including hormone precursors and processing intermediates which could not be characterised by other means at the time
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